About

The study of the relationship between sequence and their corresponding three-dimensional structure assists the structural biologists to solve the protein-folding problem. Despite several experimental and in-silico approaches, still understanding or decoding the three-dimensional structures from the sequence remains a mystery. In such cases, the accuracy of the structure prediction plays an indispensable role. To address this issue, an updated web server (CSSP-2.0) has been created to improve the accuracy of our previous version CSSP by deploying the existing highly accurate prediction algorithms. The idea is to predict the consensus three-state (Q3) secondary structures in ab-initio modeling without any template structures. The output of CSSP-2.0 avails the crystallographers to sort out the stable regular secondary structures from the entire complex structure and to infer the functional annotation of hypothetical proteins.