UniProt ID :
Q15465
Protein :
Sonic hedgehog protein
Gene :
SHH
Pathway :
Read more...
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 6 | R → T | Low | High | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 17 | L → P | High | High | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 26 | P → L | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 27 | G → A | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 31 | G → R | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 39 | L → P | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 53 | E → K | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 83 | D → V | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 84 | I → F | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 88 | D → V | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 100 | Q → H | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 102 | C → R | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 102 | C → Y | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 106 – 107 | Missing | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 109 | L → F | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 110 | A → D | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 110 | A → T | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 111 | I → F | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 111 | I → N | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 115 | N → K | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 117 | W → G | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 117 | W → R | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 124 | V → M | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 136 | E → K | High | High | Low | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 140 | H → P | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 140 | H → Q | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 143 | G → D | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 144 | R → P | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 147 | D → N | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 150 | T → K | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 150 | T → R | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 156 | S → R | High | Medium | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 170 | F → C | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 171 | D → H | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 176 – 178 | Missing | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 183 | C → F | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 183 | C → R | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 183 | C → Y | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 184 | S → L | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 188 | E → Q | High | Medium | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 196 – 200 | Missing | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 196 | G → E | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 197 | G → V | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 198 | C → F | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 198 | C → S | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 218 | L → P | Low | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 222 | D → N | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 224 | V → E | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 226 | A → T | High | High | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 231 | G → V | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 232 | R → G | Low | Medium | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 234 | L → P | High | Medium | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 236 | S → N | High | High | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 236 | S → R | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 241 | F → L | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 241 | F → V | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 255 | I → N | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 263 – 269 | Missing | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 267 | T → I | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 271 | L → P | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 275 | A → E | High | Medium | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 280 | S → W | High | High | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 290 | G → D | Low | Low | Low | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 296 | G → A | Low | Medium | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 310 | R → C | High | Medium | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 321 | R → S | Low | Medium | Low | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 332 | V → A | Low | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 346 | A → V | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 347 | P → L | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 347 | P → Q | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 347 | P → R | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 354 | I → T | Low | Medium | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 362 | S → L | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 363 | C → Y | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 364 | Y → C | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 373 | A → T | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 374 | H → R | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 376 | A → D | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 377 | F → S | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 378 – 380 | Missing | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 381 | R → P | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 382 | L → P | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 383 | A → T | High | Medium | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 391 | A → T | Low | Low | Low | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 401 – 408 | Missing | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 402 – 409 | Missing | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 404 – 408 | Missing | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 405 – 409 | Missing | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 411 | G → GG | -- | No Family | -- | -- |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 416 | T → A | Low | Low | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 424 | P → A | Low | Medium | Medium | Low |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 435 | Y → N | High | High | High | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 436 | S → L | High | High | Medium | High |
| Position | Description | Servers |
|---|
| PolyPhen-2 | Panther | MutationAssessor | Provean |
| 456 | G → R | High | High | Medium | High |